joineRML: Joint Modelling of Multivariate Longitudinal Data and Time-to-Event Outcomes
Fits the joint model proposed by Henderson and colleagues (2000) <doi:10.1093/biostatistics/1.4.465>, but extended to the case of multiple continuous longitudinal measures. The time-to-event data is modelled using a Cox proportional hazards regression model with time-varying covariates. The multiple longitudinal outcomes are modelled using a multivariate version of the Laird and Ware linear mixed model. The association is captured by a multivariate latent Gaussian process. The model is estimated using a Monte Carlo Expectation Maximization algorithm. This project was funded by the Medical Research Council (Grant number MR/M013227/1).
| Version: | 0.4.7 |
| Depends: | R (≥ 3.6.0), nlme, survival |
| Imports: | cobs, doParallel, foreach, generics, ggplot2, graphics, lme4 (≥ 1.1-8), MASS, Matrix, mvtnorm, parallel, randtoolbox, Rcpp (≥ 0.12.7), RcppArmadillo, stats, tibble, utils |
| LinkingTo: | Rcpp, RcppArmadillo |
| Suggests: | bindrcpp, dplyr, JM, joineR, knitr, rmarkdown, testthat |
| Published: | 2025-02-04 |
| DOI: | 10.32614/CRAN.package.joineRML |
| Author: | Graeme L. Hickey 
[cre, aut],
Pete Philipson
[aut],
Andrea Jorgensen
[ctb],
Ruwanthi Kolamunnage-Dona
[aut],
Paula Williamson
[ctb],
Dimitris Rizopoulos [ctb, dtc] (data/renal.rda, R/hessian.R, R/vcov.R),
Alessandro Gasparini
[aut],
Medical Research Council [fnd] (Grant number: MR/M013227/1) |
| Maintainer: | Graeme L. Hickey <graemeleehickey at gmail.com> |
| BugReports: | https://github.com/graemeleehickey/joineRML/issues |
| License: | GPL-3 | file LICENSE |
| URL: | https://github.com/graemeleehickey/joineRML |
| NeedsCompilation: | yes |
| Citation: | joineRML citation info |
| Materials: | README, NEWS |
| In views: | Survival |
| CRAN checks: | joineRML results |
Documentation:
| Reference manual: | joineRML.html , joineRML.pdf |
| Vignettes: |
joineRML and the broom package (source, R code) joineRML (source, R code) Technical details of joineRML (source) |
Downloads:
| Package source: | joineRML_0.4.7.tar.gz |
| Windows binaries: | r-devel: joineRML_0.4.7.zip, r-release: joineRML_0.4.7.zip, r-oldrel: joineRML_0.4.7.zip |
| macOS binaries: | r-release (arm64): joineRML_0.4.7.tgz, r-oldrel (arm64): joineRML_0.4.7.tgz, r-release (x86_64): joineRML_0.4.7.tgz, r-oldrel (x86_64): joineRML_0.4.7.tgz |
| Old sources: | joineRML archive |
Reverse dependencies:
| Reverse imports: | JMbdirect, jmBIG |
| Reverse suggests: | BCClong, broom |
Linking:
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