Package: MetaHD
Type: Package
Title: A Multivariate Meta-Analysis Model for High-Dimensional Data
Version: 0.1.6
Authors@R: c(
  person("Jayamini", "Liyanage", role = c("aut", "cre"),
         email = "j.liyanage@latrobe.edu.au"),
  person("Alysha", "De Livera", role = "aut",
         email = "a.delivera@latrobe.edu.au"),
  person("Luke", "Prendergast", role = "aut",
         email = "luke.prendergast@latrobe.edu.au"))
Maintainer: Jayamini Liyanage <j.liyanage@latrobe.edu.au>
Author: Jayamini Liyanage [aut, cre],
  Alysha De Livera [aut],
  Luke Prendergast [aut]
Description: Performs multivariate meta-analysis for high-dimensional data
    to integrate and collectively analyse individual-level data from multiple
    studies, as well as to combine summary estimates. This approach accounts
    for correlation between outcomes, incorporates within- and between-study
    variability, handles missing values, and uses shrinkage estimation to
    accommodate high dimensionality. The 'MetaHD' R package provides access 
    to our multivariate meta-analysis approach, along with a comprehensive 
    suite of existing meta-analysis methods, including fixed-effects and 
    random-effects models, Fisher's method, Stouffer's method, the weighted 
    Z method, Lancaster's method, the weighted Fisher's method, and vote-counting 
    approach. Visualisation tools are provided for interpreting and comparing 
    results across methods, including Venn diagrams, UpSet plots, and ROC curves, 
    heatmaps of pooled effect sizes and correlations among outcomes. A detailed 
    vignette with example datasets and code for data preparation and analysis is 
    available at <https://alyshadelivera.github.io/MetaHD_vignette/>.
License: GPL-3
Encoding: UTF-8
Depends: R (>= 4.4.0)
LazyData: true
LazyDataCompression: xz
Imports: dplyr, tidyr, metafor, corpcor, nloptr, Matrix, matrixcalc,
        Rcpp (>= 1.0.0), dynamicTreeCut, cluster, future.apply,
        metapro, metap, UpSetR, pROC, graphics, grDevices, tools,
        ComplexHeatmap, circlize
LinkingTo: Rcpp, RcppArmadillo
Suggests: gVenn, testthat (>= 3.0.0)
biocViews:
Config/roxygen2/version: 8.0.0
NeedsCompilation: yes
Packaged: 2026-07-09 00:55:12 UTC; 21460438
Repository: CRAN
Date/Publication: 2026-07-09 12:30:02 UTC
Built: R 4.6.1; x86_64-w64-mingw32; 2026-07-28 05:01:57 UTC; windows
Archs: x64
