Automatic Generation of Initial Estimates for Population Pharmacokinetic Modeling

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Documentation for package ‘nlmixr2autoinit’ version 1.0.0

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approx.vc Approximate volume of distribution from observed Cmax
bin.time Bin time-concentration data using quantile or algorithmic binning
calculate_cl Calculate clearance using an adaptive single-point method
calculate_tad Calculate time after dose for pharmacokinetic data
calculate_vd Calculates volume of distribution from concentration data
eval_perf_1cmpt Evaluates predictive performance of a one-compartment model
fallback_control Control settings for fallback rules in parameter estimation
find_best_lambdaz Find the best terminal elimination rate constant (lambdaz)
Fit_1cmpt_iv Fit intravenous pharmacokinetic data to a one-compartment linear elimination model
Fit_1cmpt_mm_iv Fit intravenous pharmacokinetic data to a one-compartment model with Michaelis-Menten elimination
Fit_1cmpt_mm_oral Fit oral pharmacokinetic data to a one-compartment model with Michaelis-Menten elimination
Fit_1cmpt_oral Fit oral pharmacokinetic data to a one-compartment linear elimination model
Fit_2cmpt_iv Fit intravenous pharmacokinetic data to a two-compartment linear elimination model
Fit_2cmpt_oral Fit oral pharmacokinetic data to a two-compartment model
Fit_3cmpt_iv Fit intravenous pharmacokinetic data to a three-compartment linear elimination model
Fit_3cmpt_oral Fit oral pharmacokinetic data to a three-compartment linear elimination model
force_find_lambdaz Forceful estimation of terminal slope
getnca Perform non-compartmental pharmacokinetic analysis
getOmegas Generate ETA variance and covariance table
getPPKinits Automated pipeline for generating initial estimates in population PK models
getsigma Compute overall residual variability from elimination phase
getsigmas Estimate individual-level residual error from the elimination phase
get_hf Estimate half-life from pooled pharmacokinetic data
get_pooled_data Generate pooled data for pharmacokinetic analysis
graphcal_iv Graphical calculation of clearance and volume of distribution (IV route)
graphcal_oral Graphical calculation of pharmacokinetic parameters for oral administration
hybrid_eval_perf_1cmpt Generate Unique Mixture Parameter Grid (with Deduplication and NA Removal)
initsControl Create full control list for initial parameter estimation
is_ss Determine steady state for pharmacokinetic observations
ka_calculation_md Calculate absorption rate constant (ka) in a multiple-dose one-compartment model
ka_calculation_sd Estimate absorption rate constant in a one-compartment oral model
ka_wanger_nelson Calculate the absorption rate constant using the Wagner-Nelson method
mark_dose_number Mark dose number
metrics. Calculate metrics for model predictive performance evaluation
nca_control Control options for non-compartmental analysis
nmpkconvert Expand additional dosing (ADDL) records for pharmacokinetic analysis
pooled_control Control settings for pooled data analysis
print.getPPKinits Print method for 'getPPKinits' objects
processData Process time–concentration dataset for pharmacokinetic analysis
run_graphcal Run graphical analysis of pharmacokinetic parameters
run_ka_solution Estimate the absorption rate constant using pointwise methods
run_npd_1cmpt_iv Run and evaluate a one-compartment IV model
run_npd_1cmpt_mm_iv Run and evaluate a one-compartment IV Michaelis-Menten model
run_npd_1cmpt_mm_oral Run and evaluate a one-compartment oral model with Michaelis-Menten kinetics
run_npd_1cmpt_oral Run and evaluate a one-compartment oral model
run_npd_2cmpt_iv Run and evaluate a two-compartment IV model
run_npd_2cmpt_oral Run and evaluate a two-compartment oral model
run_npd_3cmpt_iv Run and evaluate a three-compartment IV model
run_npd_3cmpt_oral Run and evaluate a three-compartment oral model
run_pooled_nca Performs non-compartmental analysis on pooled data
run_single_point Run full adaptive single-point PK analysis
run_single_point_base Run adaptive single-point pharmacokinetic analysis
run_single_point_extra Perform extended single-point pharmacokinetic calculations
sim_sens_1cmpt_mm Parameter sweeping for a one-compartment Michaelis-Menten model
sim_sens_2cmpt Parameter sweeping for a two-compartment pharmacokinetic model
sim_sens_3cmpt Parameter sweeping for a three-compartment pharmacokinetic model
ss_control Internal control builder for steady-state evaluation
trapezoidal_linear Linear trapezoidal rule
trapezoidal_linear_up_log_down Linear-up and log-down trapezoidal rule
trimmed_geom_mean Computes the trimmed geometric mean